Annapurna is the 10th highest mountain in the world and was the first 8000m peak to be climbed. It was first summited in 1950 by Maurice Herzog and Louis Lachenal. It was not until 1970 that Annapurna was summited again. In the autumn of 1999 there were 120 expedition to Annapurna. 106 climbers reached the summit. 54 climbers never came back.
However, I am assuming you are more interested in trekking the Annapurna region , so most of this information will pertain to trekkers considering this trip. For an excellent accounting of one persons adventure doing the Annapurna circuit and tons of nice photographs see www.cs.dartmouth.edu/whites/nepal
